Selection of the Extraction Agent and the Elaboration of the Technology of the Production
of an Extract with a Sedative Effect
SAVICKAS A., RAMANAUSKIENE K., SAVICKIENE N.1, KAZLAUSKAS S.2, MASTEIKOVÁ R.3, CHALUPOVÁ Z.3
Katedra technologie léků a OF Farmaceutické fakulty Kaunasské univerzity medicíny, Kaunas, Litevská republika 1Katedra farmaceutické chemie a farmakognozie Farmaceutické fakulty Kaunasské univerzity medicíny, Kaunas, Litevská republika2Katedra analytické a toxikologické chemie Farmaceutické fakulty Kaunasské univerzity medicíny, Kaunas, Litevská republika 3Ústav technologie léků Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno |
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Summary:
The drugsValerinae radix, Crataegi fructus,Leonuri herba and Melissae folium were used to produce
a liquid plant extract. The experiment revealed that the extraction with 70% ethanol achieved the
highest concentration of extractable active principles. The optimal conditions for obtaining a sedative
extract are established when the method of repercolation is used, and in the production itself
the batch of the drug is divided into equally large doses and a pre-prepared mixture of plant drugs
is extracted. The extract prepared by this manner remains stable for the whole period of storage,
i.e., 24 months.
Key words:
Valerianae radix – Crataegi fructus – Leonuri herba – Melissae folium – plant extract
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