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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Čes. a Slov. Farm., 50, 2001, No. 6, p. 286-289 |
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A Study of the Anticomplementary Activity of Mahonia aquifolium Crude Extract,
Bisbenzylisoquinoline Alkaloids, and Berberine KOŠŤÁLOVÁ D., BUKOVSKÝ M., KOŠČOVÁ H., KARDOŠOVÁ A. Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava, Katedra bunkovej a molekulárnej biológie liečiv Farmaceutickej fakulty Univerzity Univezita Komenského, Chemický ústav SAV, Bratislava |
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Summary: Crude extracts obtained from the stem bark of Mahonia aquifolium have been investigated as to
the chemical composition and anticomplementary activity. The results show that their anticomplementary activity is mainly due to the alkaloid components. Especially the BBI alkaloid fraction and
berberine showed a strong inhibitory effect on CH50 total hemolytic complement assay. The crude
extract of M. aquifolium was less active than berberine or the fraction BBI alkaloids. The results
indicate that the fraction of BBI alkaloids and berberine largely account for the immunomodulatory
activity of the crude extract of M. aquifolium.
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