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  Česky / Czech version Čes. slov. Farm. 52, 2003, č. 2, s. 88–92
 
Use of Penetrometry in the Evaluation of Flowability and Structure of Powdered Substances 
ZATLOUKAL Z. 

Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
 


Summary:

       Usability of modified penetrometry is examined and significant relationships with routinely used characteristics of flowability and structure of powdered substances are searched for in size fractions of sodium chloride, potassium chloride, sodium citrate, and potassium citrate. A systematic study of interrelationships between properties made it possible to achieve sufficiently reproducible results without a necessity of consolidation. By means of factor analysis, a connection between penetrometry, bulk flow rate, and Kawakita-constant was demonstrated. For multidimensional linear regresssion for estimation of penetrometry, the significance of examined properties decreases in the order Kawakita-constant > loose bulk density > total porosity > bulk flow rate > mass flow rate. The most important itemof knowledge gained in the study is the dependence of penetrometry on a combination of loose bulk density and Kawakita-constant.

        Key words: powdered substances – flowability – penetrometry – multivariation methods
       

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