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  Česky / Czech version Čes. a Slov. Farm. 48, 1999, No. 2, p. 94–96
 
A Contribution to the Analytical Profile of N-isopropyl-3-[2-acetyl-4-(propoxycarbonyl- amino)phenoxy]-2-hydroxypropylammonium Chloride (BL 343 Ac) 
BLEŠOVÁ M., CSÖLLEI J., NOVOMESKÝ P. 1 , OPATŘILOVÁ R. 

 


Summary:

       The paper presents some procedures of the analytical evaluation of a newly prepared substance with beta-adrenolytic activity. The substance was characterised by its melting point, solubility; the experimental partition coefficient, dissociation constant, surface activity were determined. The procedures for identification, purity evaluation and determination of the content of the active principle ( 1 H-NMR, 13 C-NMR, IR, UV spectra, thin-layer chromatography, acidimetric determina- tion in a non-aqueous medium, extraction titration in a heterogeneous medium, extraction-photo- metric determination) were elaborated.

        Key words: N-isopropyl-3-[2-acetyl-4-(propoxycarbonylamino)phenoxy]-2-hydroxypropyl- ammonium chloride – identification – purity detection – content determination
       

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