Tuberculosis and other mycobacterial diseases are considered to be one of the major health problems at present. Since 1985, and in particular in the 1990s, a search for new structures of antimycobac- terial substances has been one of the priorities of chemotherapeutic research. Pyrazine derivatives have always attracted the interest of research laboratories searching for new chemotherapeutic agents against tuberculosis. The present review paper, based on the journal Chemical Abstracts and original papers, surveys the attempts of the laboratories searching for new antituberculotic agents in the region of six-membered heterocyclic pyrimidine, pyrazine, and triazines compounds in recent fifteen years.

        Key words: tuberculostatics – pyrimidine – pyrazine – triazines – mycobacteria