The experiments in male rats investigated the influence of selected anticholinergic drugs (atropin, benactyzin, biperiden) on the effect of a new asymmetric bisquarternary oxime BI-6 against cholinergic and stressogenic effects of the highly toxic organophos- phate soman. The soman-induced inhibition of acetylcholinesterase in blood, diaphragm or CNS, as well as the soman-induced hypercorticosteronemia and increased activity of tyrosine aminotransferase in liver, were markedly more influenced by oxime BI-6 in combination with benactyzin or biperidine than in combination with atropin. The results obtained appear to indicate that benactyzin or biperiden are anticholinergic drugs which represent therapeutic advantage over the so far used atropin, if the poisoning is treated with oxime BI-6.

        Key words: soman, BI-6, benactyzin, biperiden, acetylcholineesterase, corticosterone, tyrosine aminotransferase, rat