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  Česky / Czech version Čes. slov. Farm. 51, 2002, No. 6, p. 305–309
 
Preparation and Physico-Chemical Properties of Alkyl Esters of [(2-Hydroxy 3-diphenyl —methylpiperazinyl)propoxy] Carbanilic Acids 
OPATŘILOVÁ R., MOKRÝ P., CSÖLLEI J., BLEŠOVÁ M. 

Ústav chemických léčiv, Farmaceutická fakulta VFU, Brno
 


Summary:

       The paper is devoted to the synthesis and study of some physico-chemical properties of a group of substances – potential antagonists of beta-adrenergic receptors. The substances are derivatives of aryloxyaminopropanol, where the basic part consists of diphenylmethylpiperazine and the aromatic part is modified with alkyl esters (methyl to butyl) of carbamic acid in positions 2-, 3-, 4-. The representation of the elements was confirmed by elemental analysis. The substances were characterized by melting point, IR and UV spectra. Their solubility and surface acitivity were determined. The purity of prepared substances was examined by means of TLC.

        Key words: preparation – aryloxyaminopropanol – surface tension – TLC
       

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