Physical-chemical parameters (surface tension, dissociation constant, RF and R M values determined by means of TLC, logarithm of the capacity factor by means of HPLC) of 30 compounds from the group of piperidinopropylesters of o-, m-, p-alkoxyphenylcarbamic acids with local-anaesthetic activity were determined. The correlation chemical structure – physical-chemical properties – local-anaesthetic activity was studied by means of QSAR. The results of the study have d emonstra- ted a linear dependence between log k, RM, and the number of C in the alkoxysubstituent.

        Key words: piperidinopropylesters of alkoxyphenylcarbamic acids – correlation structure – physical-chemical properties – biological activities