Production of a drug of good quality in the form of a hydrocream presents a wide set of complex problems. Hydrocreams as emulsions of the o/w type form a structured system which consists of at least three phases, the dispersed, crystalline hydrated, and crystalline gel one. The loading operations of manufacturing procedures can negatively affect both the individual components and the complex structure of the hydrocream. Due attention must thus be paid to the formulation study which togetherwith the conditions ofmanufacture will ensure the production of a drug with required quality indices.

        Key words: hydrocreams – structure of hydrocreams – formulation aspects