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  Česky / Czech version Čes. a slov. Farm. 49, 2000, No. 3, p. 147–149
 
Effect of Magnesium Stearate on the Inner Failure Rate of Tablets from Avicel PH 101 
MUŽÍK M., MUŽÍKOVÁ J. 

Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
 


Summary:

       The effect of the incorporation of different concentrations of magnesium stearate (0, 0.4, 0.8, and 1.2 %) on the texture of the tablets from Avicel PH 101 was investigated by means of the examination of their tensile strength and the values of Weibull’s modules. It has been found that with an increasing forming pressure the decrease in the tensile strength of tablets is increased. No significant difference in the decrease in tensile strength was found between stearate concentrations of 0.4 and 0.8 %. The incorporation of magnesium stearate into the tableting material, by decreasing the friction between the particles, minimizes possible incidence of more marked disorders in the texture of tablets.

        Key words: Avicel PH 101 – magnesium stearate – tensile strength of tablets – structure
       

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