|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Čes. a Slov. Farm. 48, 1999, No. 1, p. 21–26|
A Study of Labeling Conditions of Derivatives of (2RS, 4R)-1,3-Carboxylic Acid with Technetium-99m
BUMBÁLOVÁ A., HAVRÁNEK E., JA’AFREH J., KETTMANN V., SVĚTLÍK J., ŠTROFFEKOVÁ O.
The preparation of 99m Tc-complexes with twenty derivatives of (2RS,
4R)-1,3-thiazolidin-4-carboxy- lic acid over a broad pH range (1.5–8.9) is described for
a potential use in radiodiagnostic medicine. The labelling efficiency was checked by paper
and thin layer chromatography and for all well-soluble compounds is higher than 90 %.
Paper electrophoresis and gel chromatography indicated the presence of two types of
complexes differing in charge and molecular mass. The structure of both types of the 99m
Tc-complexes is also discussed. The organ distribution and its time dependence were
determined in mice after i.v. application.
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