CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ | |
Journals - Article | |
Česky / Czech version | Ces. slov. Farm., 2005; 54, 23-28 |
Adsorption of Substances on Active Charcoal
Part 2: Basic Esters of Phenylcarbamic Acid with Beta-adrenolytic Effect
STANKOVIČOVÁ M., ZLEVSKÁ Z., BEZÁKOVÁ Ž., MOKRÝ P.1, CSÓLLEI J.1 Katedra farmaceutické] chemie Farmaceutickej fakulty Univerzity Komenského, Bratislava 'Ústav chemických léčiv Farmaceutickej fakulty Veterinárnej a farmaceutickej Univerzity. Brno |
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Summary: The páper is concerned with the study of adsorption on active charcoal in a set of selected substances from the group of aryloxyaminopropanol derivatives with carbamate substitution on the benzene ring with beta-adrenolytic effect (Group A) and a set of substances, derivatives of [(arylcarbonyí)oxy]aminopropano1 with the identi-cal, but assumed ultra-short effect (Group B), where the effect was produced by replacing the phenolether group with a metabolically unstable ester functional group. The course of adsorption in buffer solution with pH 7 in dependence on time and concentration is examined. Adsorptivity of substances is evaluated according to Fre-undlich and Langmuir models. Affinity of substances of Group A to adsorption materiál decreases with increa-sing hydrophilicity.
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