Sildenafil for Treatment of Erectile Dysfunction in Men
with Chronic Carbon Disulfide Intoxication*
Bátora I.1, Orszag A.1, Vrabec J.2, Farkašová D.3
1Department of Industrial Medicine and Toxicology, School of Medicine Comenius University, Bratislava, Slovakia, Head: Igor Batora, MD, PhD, Associate professor 2Medical Sexology Institute, Bratislava, Slovakia, Head: Jan Vrabec, MD, PhD, Associate professor 3Pfizer H.C.P. Slovakia |
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Summary:
Occurrence of erectile dysfunction (ED) in viscose rayon workers with chronic carbon disulfide (CS2) intoxication recognized
as an occupational disease is well known. The aim of the study was to evaluate the efficacy of sildenafil in patients with ED
attributable to chronic CS2 intoxication. Seventeen men were former rayon workers with ED and chronic CS2 intoxication
recognized as an occupational disease. The sildenafil efficacy was assessed using the responses to questions according to the
International Index of Erectile Function (IIEF). A positive response was recorded in all 17 patients. After treatment with sildenafil,
a significant score difference was observed in all IIEF questions with the exception of Question 12 (rating of sexual desire).
Moreover, the treatment with sildenafil significantly improved the ability to achieve and maintain an erection also in all subgroups
of men with ED (age, duration of ED, duration of CS2 exposure and antidepressant medication). Sildenafil was an effective,
reliable, and well-tolerated treatment of erectile dysfunction in men with chronic carbon disulfide intoxication.
Key words:
sildenafil, erectile dysfunction, carbon disulfide
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