Commencing with 1 January 2000, law No. 157/98 of the Coll. in the wording of law 352/99 of the Coll., government orders No. 25/99 of the Coll., 258/2001 of the collection, and other implementation regulations based on the regulations and directives of the European Community have been valid for the handling of chemical substances and preparations in the Czech Republic. The present paper discusses and comments on the parts of the law which are important for the management and running of the establishments engaged in the synthesis or analysis of drugs. It further lists examples of highly toxic chemical substances which can occur at these establishments.

        Key words: law on chemical substances – highly toxic substances