The author presents the history of the Centre for Travel Medicine at the Clinic of Occupational Diseases of the Faculty Hospital Hradec Králové in 1975-2001. During this period they made 87 501 examinations of subjects travelling abroad. From the nationwide notified number of 1089 occupational tropical diseases their centre notified 284 infectious and parasitic occupational diseases, i.e. 26% of the total number in the Czech during that period. Consistent with the nationwide statistics most frequently malaria was reported: in the whole CR 481 cases, in the mentioned centre 144 which is almost 30%. One of these cases in Nigeria was fatal when anti-malaria prophylaxis with Lariam failed. The second most frequent diseases in the CR was viral hepatitis, almost all cases were type A, a total of 146, in the Centre of Travel Medicine in Hradec Králové only 28 cases which is 11%. The third place was held in the CR by 164 amoebiasis incl. 81 reported by the Centre in Hradec Králové i.e. 49%. The highest number of notified tropical diseases was in 1977, 1981, 1984 and 1995 which correlates with nationwide figures. The author presents also experience with clinical and laboratory manifestations of different groups of tropical diseases and treatment, incl. Two published cases of beri-beri notified as other occupational damage from Peru and Nigeria. She also draws attention to some problems of immunization before trips abroad.

        Key words: Centre of Travel Medicine, occupational tropical diseases, malaria, amoebiasis, immunization