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  Česky / Czech version Čes. a Slov. Farm., 50, 2001, No. 4, p. 166-172
 
Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics 
ROJKOVIČOVÁ T., LEHOTAY J., ČIŽMÁRIK J.  

Katedra analytickej chémie Chemickotechnologickej fakulty Slovenskej technickej univerzity, Bratislava, Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
 


Summary:

       The present review paper describes the properties of the macrocyclic antibiotics vancomycin, teikoplanin, and ristocetin A, which can be used as stationary phases for separation of the enantiomers of drugs containing a stereogenic centre. It analyzes the results obtained in the separation of amino acids, its derivatives, loxiglumide, clenbuterol, practolol, carnitine, levodopa, methyldopa, ceftazidine, alkoxyphenylcarbamic acid derivatives, dichloroprop, ketoprofen, warfarin, and ergot alkaloids by means of high-performance liquid chromatography (HPLC)

        Key words: vancomycin - teikoplanin - ristocetin A - stationary phases - properties - separation of enantiomers - HPLC
       

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