The physico-chemical parameters (surface tension, dissociation constants, experimental partition coefficient, RF and RM values by means of thin-layer chromatography, logarithm of the capacity factor with the help of HPLC) of 8 newly synthetic drugs from the group of 1-(4-phehyl-1-piperazi- nyl)-3-methoxy-2-propylesters of 2-, 3-alkoxyphenylcarbamic acids with assumed local anaesthetic, anti-arrhythmic, and antiulcerous activity were determined. The structure – physico-chemical properties relationship was investigated by means of QSAR.

        Key words: 1-(4-phenyl-1-piperazinyl)-3-methoxy-2-propylesters of 2-, 3-alkoxyphenylcarbamic acids – physico-chemical properties – correlations