Failure of Vaccination against Haemophilus Influenzae Type b
Táborská J.1, Gutová V.2, Koubová A.1, Pazdiora P.3, Lebedová V.4
Infekční klinika Fakultní nemocnice, Plzeň1 přednostka MUDr. J. Táborská, PhD. Ústav imunologie a alergologie LF UK, Plzeň2 přednosta doc. MUDr. P. Panzner, CSc. Ústav epidemiologie LF UK, Plzeň3 vedoucí doc. MUDr. P. Pazdiora, CSc. Národní referenční laboratoř pro hemofilové nákazy, Centrum epidemiologie a mikrobiologie, SZÚ, Praha4 vedoucí MUDr. V. Lebedová |
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Summary:
The authors present a case report of a 19-month child regularly vaccinated with three doses of
the vaccine against invasive infections caused by Haemophilus influenzae type b (Hib). In spite of
that the patient suffered from bacterial meningitis caused exactly by this microbial strain. The
immunological examination demonstrated a deficiency of serum immunoglobulins IgA and IgG,
which was probably the cause of insufficient production of antibodies against polyribosil-ribitolphosphate
(PRP) antigen Hib after the vaccination and, also, the cause of the disease development.
The problems in failure of vaccination against Hib are discussed.
Key words:
Haemophilus influenzae type b, vaccination, meningitis
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