Concomitant radiochemotherapy is the most effective approach in the treatment of esophageal, gastric and pancreatic cancer. Standard treatment of advanced or metastatic colorectal carcinoma was 5-fluorouracil and leukovorin combination (Mayo combination). In comparison with this schedule present the new drugs raltitrexed and capecitabin less toxicity and equivalent efficacy. Combination oxaliplatin 5-FU/FA is superior in response rate to the standard 5-FU/FA combination.

        Key words: Gastrointestinal cancer - Concomitant radiochemotherapy - Chemotherapy