During the last decade recombinant DNA technologies have facilitated development and production of haemopoietic growth factor (colony stimulating factors - CSF) which stimulate the proliferation and maturation of haematopoietic cells. CSF (mainly granulocyte and granulocyte macrophage CSF) in children is widely used despite the absence of conclusive supportive data, and despite the high cost of these d rugs. This review is devoted to one of the most controversial, but most common reason for their use prophylactic use. A summary of recomended uses of the CSF in paediatric oncology is presented praxis and relevant clinical studies are discussed.

        Key words: haemopoietic growth factors (CSF), use in child oncology