Vesicouretheral reflux (VUR) is an inherited abnormality of the urinary tract frequently accompanied by recurrent urinary infections. The standard therapeutical approach comprises surgical correction and consequent long-term prophylactic antibiotic therapy. Authors present case report of a paediatric patient with VUR suffering from recurrent urinary infections. The use of standard therapy failed. After assessment of secondary deficiency in T cell mediated immunity, combined immunomodulatory therapy (transfer factor, preparation Immodin inj., in dose 1 inj. s.c., once weekly - 3 weeks follow up, 4th and 5th inj. in every 4 weeks lasting intervals and bacterial lysate, preparation Uro-Vaxom in dose 1 caps. daily, during the period of 3 months) was administered. High clinical efficacy was observed with long-term (2.5 yrs) absence of urinary infection.

        Key words: immunostimulating treatment, bacterial lysate, transfer factor, relapsing uroinfection, vesicouretheral reflux