Breast Cancer Cell Populations and its Changes Relation to Therapy
Kolařík D.1, Netíková I.2, Marinov I.3, Juliš I.4, Halaška M. jr.5, Rauš K.1, Driák D.1, Záhumenský J.1, Benková K.6, Halaška M.1
1Gynekologicko-porodnická klinika 1. LF UK a FN na Bulovce, Praha, přednosta prof. MUDr. M. Halaška, DrSc.2Onkologická klinika 1. LF UK a VFN, Praha, přednosta doc. MUDr. L. Petruželka, CSc.3ÚHKT, Praha, přednosta prof. MUDr. P. Klener, DrSc. 4Biolab s.r.o., Praha 5Gynekologicko-porodnická klinika 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. L. Rob, CSc. 6Ústav patol. a soud. lékařství, FN na Bulovce, Praha, prim. MUDr. K. Benková |
|
Summary:
This review summarizes the data from published studies that dealt with observation of various bioparameters
changes in cancer population dependant on used therapy. Critically evaluating these studies and
looking for relations among separate results we are trying to estimate prognostic value of these parameters
(likelihood of recurrence, overall survival, ...) and also their value for prediction of tumor response
to cytostatic, hormonal or other treatment. The aim is selection of such tumor population characteristics
the testing of them would enable better patient stratification in postoperative adjuvant systemic therapy.
Key words:
breast cancer, chemotherapy, cellular changes, hormonal therapy
|
