Well differential inflammatory liposarcoma is a rare type of low grade liposarcoma. Its microsco- pical features may simulate benign inflammatory pseudotumor. A case of this lesion was descri- bed occurring in the subcutis of the right supraclavicular region in 61-year-old woman. The tumor was round well circumscribed and measured 3 cm in diameter. Histologically, it contained a 1,5 cm inflammatory nodule, which was surrounded by otherwise typical lipoma-like liposarco- ma. The inflammatory nodule was composed of lymphocytic aggregates and spindle to stellate cells with mild atypism. No lipoblasts were seen in this area which mimicked an inflammatory pseudotumor. Correct diagnosis was based on the recognition of the lipoma-like liposarcoma area in this lesion. Our patient had no recurrence six years after the tumor excision.

        Key words: liposarcoma - inflammatory pseudotumor - soft tissue