Cyclic vomiting syndrome is a child as well as adult diagnosis. Prevalence of the syndrome in childhood is 1.9%. This syndrome is identified by the occurrence of three or more episodes of intractable nausea and repeated vomiting, sometimes with accompanying symptoms; there are completely asymptomatic intervals between each episode.Various organic gastrointestinal, neurologic and metabolic disorders must be excluded before the diagnosis is made. In this article, possible causes, pathophysiological ways, course, clinical approach and therapy of various phases of the syndrome are discussed.

        Key words: vomiting, cyclic vomiting, diagnosis, differential diagnosis, therapy, drugs