Neuroblastoma is the most common malignant tumour in infants. For all Patients with neuroblastoma, age, stage, and tumour biology (such as MYCN copy number, DNA Ploidy, type of histology) are the most important variables influencing Prognosis. Children less than ope year-old with localized tumours have a five-year survival in more than 90 %, whereas in older children with advanced disease the long-term survival is less than 30 %, despite very intensive therapy. In younger patients with localized disease it is aPPropriate to test Possible ways of declining treatment intensity, reducing thus treatment - related morbidity and mortality. There is increasing evidence in the literature that spontaneous regression is Possible in some neuroblastomas, but standard treatment in infants with localized disease is sbil immediate surgical resection. In this Paper two Patients with localized neuroblastoma are Presented where the „wait and watch aPProach" was successfully used, incl. a review of the literature.

        Key words: low risk neuroblastoma, surgery risk, follow-uP