CzMA JEP Home page CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ
Journals - Article
CzMA JEP Home page News About Assocation Publishing Division Medical Journals Searching Supplements Catalogue
 
  Česky / Czech version Čas. Lék. čes., 2004, 143, pp. 295–298.
 
Cloning of Mammals – Biological Aspects 
1 , 2Fulka J., Jr., 2Mrázek M. 

1Centrum buněčné terapie a tkáňových náhrad – laboratoře VÚŽV 2. LF UK a FNM, Praha 2ISCARE IVF, Praha
 


Summary:

       Cloning by somatic cell nucleus transfer into enucleated oocytes represents a very straightforward approach. The nucleus is simply transferred into the oocyte from which its nuclear genetic material (chromosomes) has been earlier removed.By using this approach clones of sheep, cattle, horse, rabbit, goat, rat,mule, pig, cat and interspecies-specific clone mouflon x sheep were obtained. The success of cloning is, however, disappointingly low and only 1–3 % of reconstructed embryos develop to term. Some cloned animals are abnormal and die prematurely. This clearly speaks against the use of cloning in humans. On the other hand, so called therapeutic cloning, when the nucleus is transferred into an oocyte and the developing embryo is then used for the production of embryonic stem cells is generally well accepted. This promising techniqe may be probably used in some as yet untreatable diseases and in certain serious injuries.

        Key words: cloning, nucleus, oocyte, embryonic stem cells.
       

Order this issue

  BACK TO CONTENTS  
 
 
| HOME PAGE | CODE PAGE | CZECH VERSION |
©  1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o.
WEBMASTER