Unusual Cause of Severe Lactate Acidosis in a Seven-month Child
Behúlová D.1, Fabriciová K.2, Bzdúch V.2, Buzassyová D.3, Škodová J.1,Šalingová A.1, Vasilenková A.1, Ponec J.1
Oddelenie klinickej biochémie DFNsP, Bratislava1 primárka MUDr. D. Behúlová 1. detská klinika Lekárskej fakulty UK a DFNsP, Bratislava2 prednostka doc. MUDr. M. Benedeková, PhD.Detská klinika anestéziológie a intenzívnej medicíny SZU a DFNsP, Bratislava3 prednosta prof. MUDr. T. Šagát, CSc. |
|
Summary:
The authors describe a female patient with a serious lactate acidosis, which became manifest at the age of seven
months. The clinical picture was dominated by neurological and cardiological symptomatology of uncertain
etiology. An urgent examination excluded an inherited developmental anomaly, poisoning or infectious diseases.
Non-specific findings during specific biochemical examinations did not confirm suspected hereditary metabolic
disorder. In view of the resistance of lactate acidosis to alkalization therapy and for a deteriorating clinical condition
of the child the authors administered 25 mg of thiamin intramuscularly. After six hours the lactate concentration
decreased to normal values and the clinical sings of the child gradually adjusted to normal condition. The mother
of the patient admitted that instead of giving the child the recommended Nutrilon Soya, she gave the child a dry
soya drink without thiamin purchased in a common grocery. A detailed analysis of the clinical course and
laboratory findings confirmed that the little child suffered from a suckling form of beri-beri.
Key words:
lactate acidosis, thiamin, beri-beri, the suckling age
|