Extrusion/spheronization is the method used to manufacture pellets with a high content of the active
ingredient. It produces particles of very good physical properties (strength, friability, porosity,
density, uniform diameter), which are well processed in further steps, i.e., when they are coated,
compressed or filled into hard gelatine capsules. The process of extrusion/spheroniztion consists of
several consequential steps, which are influenced by numerous formulation and process factors.
Though there are general rules for optimization of the process, due to its complexity the same rules
need not necessarily be valid for similar systems and very often it is necessary to find again the
optimal production condition for a new formulation and equipment. The paper informs about the
technology, equipment, and the result achieved in the field.
pellets – extrusion/spheronization – extrudate – formulation factors – process factors