Reference intervals, optimal and target
values in the context of the clinical interpretation of lipid profile
Franeková J.1, Friedecký B.2, 4, Jabor A.3, Palička V.4, Stožický F.5, Soška V.6
1Ústav klinické biochemie, Fakultní nemocnice s poliklinikou, Ostrava-Poruba 2SEKK, spol. s r. o., Pardubice 3Úsek laboratorních metod, IKEM, Praha 4Ústav klinické biochemie a diagnostiky, LF UK Hradec Králové 5Dětská klinika, Fakultní nemocnice Plzeň 5Dětská klinika, Fakultní nemocnice Plzeň 6Oddělení klinické biochemie, Fakultní nemocnice u sv. Anny, Brno |
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Summary:
The authors offer the solution of the problem with lipid reference intervals used in laboratory information systems (LIS).
Definitions of reference interval (2.5–97.5 percentile of concentrations measured in a defined population or measured
in reference individuals with known health status), optimal values (best values for the discrimination of cardiovascular
risk) and target values (therapeutic target adjusted to cardiovascular risk in specific groups of patients) are given. The
authors reject the use of reference intervals as defined above in LIS and recommend the use of optimal values
harmonized with Czech national societies guidelines for upper limit of cholesterol (Ch), LDL cholesterol (LDL Ch) and
triglycerides (TAG), or lower limit of HDL cholesterol (HDL Ch), respectively. They recommend to use the NORIP study
limits for lower limits of Ch, LDL Ch and TAG, or upper limit of HDL Ch, respectively. Similarly, the same approach is
recommended for children. Target values are treated in a form of simple and instructive algorithm, based on national
recommendation for the prevention of cardiovascular diseases in adults.
Key words:
cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, reference intervals, optimal values, target values.
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