Palmo-plantar erythrodysesthesia (PPE) is a relatively frequent manifestation of the side-effects of chemotherapy in the skin. It has a clear-out clinical picture, non-specific histology and unclear pathogenesis. Its course in patients often calls for modification and sometimes interruption of otherwise effective chemotherapy. There is no specific treatment, however, there has been described the possible application of certain drugs in cases of chemotherapeutics with which the risk of PPE is most often connected (doxorubicin, cytarabin, docetaxel, fluorouracil). The author describes a clinical case of PPE upon application of liposome-encapsulated doxorubicin in a patient suffering from ovarial carcinoma.

        Key words: chemotherapy - doxorubicin - side-effects - erythrodysesthesia