Mixed Form of Acute Child Leukaemia with Hybrid Translocation of the bcr/abl Gene of the Ph Chromosome
Čáp J., Kaiserová E., Kirschnerová G., Babušíková O.
Oddelenie detskej onkológie Detskej fakultnej nemocnice s poliklinikou, Bratislava Oddelenie genetiky nádorov, Národný onkologický ústav, Bratislava 0ddelenie imunológie nádorov, Ústav experimentálnej onkológie Slovenskej akadémie vied, Bratislava |
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Summary:
Authors present the tase-history of an 11-year-old boy with the bilinear (lymphoid and myeloid) form of acute leukaemia. The immature type of acute lymphoblastic leukaemia changes very early in to bilinear acute leukaemia (lymphoid and myeloid) combined with the presence of the pathological hybrid translocation gene bcr/abl Ph Chromosome. Intensive chemotherapy with antracyclines, alkylating agents and epipodophyllotoxins followed by allogeneic bone marrow transplantation led to complete remission lasting 7 months, but did not prevent fatal outcome of the disease.
Key words:
mixed/biclonal acute leukaemia, karyotyping, immunophenotyping, hybrid translocation gene bcr/abl Ph Chromosome
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