There are continuously increasing information on acne pathogenesis which bring new views on yet unexplained causes of origin and chronicity of the disease. The great deal of these infomation is due to the progress in immunohistochemistry techniques. This publication focuses on keratinization, hyperseborrhea and microorganisms’ role including influence of androgens on these basic pathogenetic factors. The article supplements already published separate paper in this journal: „Therapeutic principles in dermatology – Acne vulgaris” (Ces.-slov. Derm. 5, 2006).

        Key words: acne vulgaris – keratinization – seborrhea – microorganism – androgens