Prenatal Diagnosis of Inborn Devects - Detection of Foetal Cells in the Maternal Circulation with Subsequent Genetic Analysis
Calda. Stanczová, Kapras
Ústav biologie a lékařské genetiky 1. LF UK VFN Praha, přednosta doc. MUDr. Jan Kapras, CSc., Gynek-porod klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. Jaroslav Živný, DrSc. |
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Summary:
Objective: To summarize the findings regarding the possibility of prenatal diagnosis on the basis
of isolation and examination of fetal cells and fetal DNA in the maternal circulation.
Type of Study: Review.
Setting: The Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and the General Faculty Hospital, Apolinářská 18, 128 51 Prague 2, Czech Republic.
Methods: Analysis of literature.
Results: An overview of the presently used noninvasive methods of prenatal diagnosis based on
the isolation and examination of fetal cells in the maternal circulation. A new method, the analysis of free/unbound fetal DNA in the maternal plasma and serum enables more accurate DNA
diagnosis than DNA acquired from fetal cells.
Conclusion: Several methods mentioned are as yet experimental, and have not been used in
clinical practice.
Key words:
prenatal diagnosis, fetal cells in the maternal circulation, fetal DNA in the maternal
circulation
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