Results of Growth Hormone Treatment of Girls with Turner’s Syndrome in Slovakia
Šimeková Z.1, Bieliková S.2, Gondová A.3, Košťálová Ľ.4, Milošovičová B.5,Mišíková Ž.4, Pašková M.6, Pribilincová Z.4, Šandriková V.7
Detské oddelenie NsP, Žilina1 primárka MUDr. D. SalátováDetská klinika NsP F. D. Roosevelta, Banská Bystrica2prednosta prof. MUDr. S. Dluholucký, CSc. I. detská klinika DFNsP a LFUK, Bratislava3 prednostka doc. MUDr. M. Benedeková, PhD.II. detská klinika DFNsP a LFUK, Bratislava4 prednosta prof. MUDr. L. Kovács, DrSc. Detská klinika SZU NsP sv. Cyrila a Metoda, Bratislava5 prednostka doc. MUDr. K. Furková, CSc. Detská nemocnica, Košice6riaditeľka MUDr. I. Marinová, PhD. Detská endokrinologická ambulancia, Prievidza7 |
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Summary:
The main features of Turner’s syndrom (TS) are short stature and ovarian failure. Although the majority of
girls with TS are not growth hormone deficient, growth hormone therapy is effective in improving their final height.
The present paper report the results of a Slovak retrospective study of growth hormone therapy of 55 girls with
TS who reached their final height. The mean age at the start of growth hormone treatment was 12.4 ± 2.1 years,
the mean height SDS -3.4 ± 1.0, the mean duration of treatment 4.1 ± 1.4 years. The final height of the girls was
153 ± 5.4 cm. The benefit resulting from growth - promoting therapy (final height - predicted adult height) is 7.1
cm.
Better results can be obtained with an earlier start of therapy, normalising height in childhood and inducing
puberty at an appropriate age.
Key words:
Turner syndrome, growth hormone therapy, final height
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