Histopathological Prognostic Factors, Serum Markers
and Selected Molecular Biological Factors in Ovarian
Cancer
Špaček J.1, Jílek P.2, Petera J.3, Tesařík Z.4
1Klinika porodnictví a gynekologie, LF UK v Hradci Králové, přednosta doc. MUDr. J. Tošner, CSc. 2Katedra biologických a lékařských věd, FaF v Hradci Králové, přednosta doc. RNDr. V. Semecký, CSc. 3Klinika onkologie a radiologie, LF UK v Hradci Králové, přednosta doc. MUDr. J. Petera, PhD. 4Bristol-Myers Squibb, s.r.o. Onkologická divize, Praha |
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Summary:
Objective: A review of histopathological prognostic factors, serum markers and selected molecular
biological factors in ovarian cancer.
Design: Review.
Setting: Department of Obstetrics and Gynaecology, Medical Faculty Hradec Králové, Charles
University, Prague; Department of Biological and Medical sciences, Pharmaceutical Faculty, Hradec
Králové, Charles University, Prague; Department of Clinical Oncology, Medical Faculty Hradec
Králové, Charles University, Prague; Bristol-Myers Squibb, Department of Oncology, Prague.
Method: Discussion about current evidence from literature.
Conclusion: Except clinical prognostic factors the wide spectrum behaviour of epithelial ovarian
cancers is reflected by some histopathological prognostic factors, serum markers and some molecular
biological factors. The most important are grade and tumor ploidy, the level of CA 125 and
its changes during the treatment, mutations of p53, BRCA 1 and 2.
Key words:
ovarian cancer, histopathological prognostic factor, grade, ploidy analysis
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