Epidermolysis bullosa simplex (EBS) belongs into the group of inborn mechanobullous diseases mostly with an autosomal dominant inheritance. The development of the clinical picture, correct collection of a new blister and experience with the histological diagnosis incl. electron microscopy are the basis for correct diagnosis. Patients, in particular those with the localized form of epidermolysis bullosa simplex frequentl y escape the attention of doctors. The authors discuss their own experience with the diagnosis of 18 patients with EBS.

        Key words: epidermolysis bullosa simplex, clinical picture, electron microscopy, concentration of patients into