Long-term systemic antimycotic therapy, which is necessary in dermatology indications as e.g. in onychomycosis, is associated with concern of certain risk of hepatotoxicity. The frequency of liver damage after application of ketoconazole is 1:15 000, after terbinafine 1:45 000-50 000, after itraconazole pulse-therapy 3.2:100 000 and after intermittent fluconazole therapy 1.4:100 000. The safety of modern antimycotics is comparable e.g. with paracetamol (toxic reactions rate 5.5:100 000) or ibuprofen (toxic liver damage appeared in 2 of 54 830 treated).

        Key words: systemic antimycotics - hepatotoxicity