The authors compared within the framework of a randomized comparative study necessary analgosedation during HFOV and CV during treatment of non-complicated RDS in VLBWneonates. For basic analgosedation the authors used opioids (sufentanil, fentanyl) which were, if necessary, combined with flunitrazepam. Myorela- xants (alcuronium) were added only in exceptional cases. The level of analgosedation depended on the patient´s clinical condition. A total of 30 patients in two groups were evaluated (HFOV n = 16, CV n = 14). The total period of analgosedation was compared, the number of patients receiving different preparations and cumulative daily doses of opioids and flunitrazepam. The mean period of analgosedation and its median was lower in group HFOV but the difference did not reach statistical significance (p = 0.068). The number of patients sedated with opioids and flunitrazepam was higher in group CV and on the 4th - 5th day of life the difference was statistically significant (opioids p < 0.025, flunitrazepam p < 0.05). In both groups after the 4th and 5th day, due to onset of tolerance the cumulative daily doses of opioids increased. The differences of cumulative daily doses of different preparations between groups were not statistically significant. The differences in the total ventilation period between groups were not statistically significant.

        Key words: premature neonate, analgosedation, opioids, ventilation, HFOV, RDS