CzMA JEP Home page CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ
Journals - Article
CzMA JEP Home page News About Assocation Publishing Division Medical Journals Searching Supplements Catalogue
 
  Česky / Czech version Vnitř. Lék., 49, 203, No. 11, p. 845 - 850
 
Factor V Leiden and the Slovak Population 
Hudeček J.1, Dobrotová M.1, Hybenová J.2, Ivanková J.1, Meluš V.2, Pullmann R.2, Kubisz P. 

1Klinika hematológie a transfuziológie MFN a JLF UK, Martin, Slovenská republika, přednosta prof. MUDr. P. Kubisz, DrSc.2Ústav klinickej biochémie MFN a JLF UK, Martin, Slovenská republika, přednosta prof. RNDr. MUDr. R. Pullmann, PhD.
 


Summary:

       The resistance to activated protein C (APC-resistance) based on the presence of factor V Leiden (F V Leiden) is the most frequent thrombophilic condition in the white race population. It contributes to the origin of thrombosis especially in the venous part of blood vessels. Significant geographic differences have been detected within Europe. The aim of this retrospective study was to determine the frequency in the occurrence of F V Leiden: 1. in healthy (asymptomatic) Slovak population, 2. in their consanguineously unrelated members with thrombosis and 3. in patients with myocardial infarction (IM) without or with other known risk factors of this disease (nicotinism, obesity, hypertension, dyslipoproteinemia, diabetes mellitus), respectively. The detection of FV Leiden was made by molecular biology methods. The occurrence in a group of 152 healthy individuals was four % (6 persons) and this frequency corresponds to the geographic localization of the Slovak Republic in Europe. In a group of 349 patients with thrombosis in anamnesis, FV Leiden was detected in 103 persons (29.5 %). The occurrence was higher than the usually reported incidence in these patients (20 %). Likewise, in a group of 35 patients with IM without risk factors in anamnesis, the occurrence of FV Leiden (8.6 %) was significantly higher in comparison with healthy population and the incidence further increased significantly in a group of 41 patients with IM and the presence of at least one risk factor (14.6 %). The authors therefore suppose an active role of the Leiden mutation of FV gene in the pathogenesis of this disease.

        Key words: Factor V Leiden - Resistance to activated protein C - Slovak population - Thrombosis - Myocardial infarction
       

Order this issue

  BACK TO CONTENTS  
 
 
| HOME PAGE | CODE PAGE | CZECH VERSION |
©  1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o.
WEBMASTER