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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Klin. Biochem. Metab., 6 (27), 1998, No. 4, p. 226–229 |
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Relation of Intrathecal Synthesis of IgG Including IgG Subclasses to Cytokine Levels in Cerebrospinal Fluid in Patients with Multiple Sclerosis Havrdová E., Racek P., Jedlička P. 1 Neurologická klinika, 1. lékařská fakulta Univerzity Karlovy, Praha 2 Imunologická laboratoř, Brno-Modřice 3 Neurologická klinika, IPVZ Fakultní Thomayerova nemocnice, Praha |
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Summary: Intrathecally produced IgG is detected in multiple sclerosis, an inflammatory demyelinating disease of the CNS with autoimmune pathogenesis. This IgG consists mainly of IgG1 subclass for which help of T cells recognizing their antigen and producing cytokines which change the IgG subclass production to IgG1 and cause B cell proliferation, is needed. We investigated cerebrospinal fluid (CSF) from 61 patients with MS, examined the integrity of the blood-brain-barrier, intrathecal IgG production, oligoclonal bands, levels of interleukin-2, interleukin-4, interleukin-6, interleukin-10 and tumour necrosis factor-a. We did not find any correlation between these parameters in a single CSF examination.
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