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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Čes.-slov. Patol., 39, 2003, No. 3, p. 138 - 142 |
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2p13-16 Amplification in Extranodal Diffuse Large B-cell Lymphoma with
Rapid Lethal Course Resistent to Chemotherapy: a Case Report Hušek K.1, Peťovská P.2, Procházková D.3 1I. patologickoanatomický ústav MU, FN u sv. Anny, Brno 2Oddělení lékařské genetiky MU, FN u sv. Anny, Brno 3I. dětská interní klinika, FN Brno, pracoviště Dětská nemocnice, Brno |
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Summary: Comparative genomic hybridisation (CGH) allows to detect genetic abnormalities associated with
poor prognosis in subset of patients with diffuse large B-cell lymphoma (DLBCL). Amplification of
2p13-16 represents an adverse genetic sign especially in extranodal DLBCL. In the present case,
2p13-16 amplification was revealed by CGH in extranodal DLBCL. It was localized in the mesentery
and remained resistant to the chemotherapy (CHOP). A patient, 72-year-old female, died 10
weeks after the diagnosis had been made. Rapid lethal course of the disease confirms poor
outlook for patients with 2p13-16 and supports a role of CGH as a sensitive method in prognosis
for patients with DLBCL.
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