Warning Symptoms Preceding the Development of Septic Shock in
Neutropenic Patients Treated on Acoount of Haematological Malignities
Kubešová, H., Penka, M., Král, Z., Vášová, I., Hájek, R., Adam, Z., Navrátil, M.
Background. In patients with haematological malignities infectious complications take a very rapid course, and
in particular during the period of neutropenia, they are not necessarily manifested by a clear symptomatology.
Frequently they may be manifested only by an elevated temperature and general deterioration of the condition. The
onset of shock then can be rapid and surprising. The objective of the work was to identify clinical and laboratory
signs warning against the possible development of septic shock.
Methods and Results. The investigation comprised a total of 38 patients hospitalised due to infectious compli-
cations at the intensive care unit because of general deterioration of the condition. 18 developed septic shock (group
S), the remaining 20 (group N) achieved during hospitalisation at the ICU a stabilised condition. In both groups the
laboratory values and clinical condition were followed up for 2-3 days prior to deterioration of the condition. Risk
factors for development of septic shock in the group of investigated patients were: unusual weakness, heart rate
above 95/min. beyond the temperature peak, hypoalbuminaemia, mucositis, hypokalaemia, presence of a central
venous catheter and administration of parenteral nutrition.
septic shock, risk factors, oncohaematological disease.