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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Vnitř. Lék., 44, 1998, No. 11, p. 661 - 664 |
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Tissue Plasminogen Activator and Diabetes Mellitus Galajda, P., Martinka, E., Kubisz, P., Mokáň, M. 1 I. interná klinika MFN, Martin, prednosta prof. MUDr. Mokáň M., DrSc. 2 Národné centrum hemostázy a trombózy, Martin, prednosta prof. MUDr. Kubisz P., DrSc. |
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Summary: tPA has been the independent risk factor of the thrombosis associated with atherosclerosis. There are increased tPA levels in type 1 diabetic patients with vascular complications and tPA is endothelial injury marker in this case. In type 2 diabetes mellitus elevated tPA antigen levels in early disease stage are caused by increased production of complexes with inhibitor (PAI-1) and tPA or fibrinolytic activity has been decreased.
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