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  Česky / Czech version Čes. a slov. Oftal., 56, 2000, No. 4, p. 203 - 209
 
Protective Role of Pilocarpine and Taurine in the Pigmented Retinal Epithelium, in the Retina and Optic Nerve 
Veselovský J., Oláh Z., Veselá A. 

Katedra živočíšnej fyziológie a etológie Prir. Fak. UK, Bratislava, SR,
 


Summary:

       Chromatoghraphic analysis under in vivo conditions in bovine eyes revealed that after instillation of 3% pilocarpine into the conjunctival sac, 2 and a half hours after their last administration, that this alkaloid penetrates also into the posterior tissue structures , i.e. into the pigmented retinal epithelium, central and periphe- ral portion of the retina and optic nerve. The authors recorded its interaction with the amino acid taurine. The assembled results provide evidence that in the investigated tissue structures: 1. the taurine level of all amino acids is present in ther highest concentration, 2. pilocarpine increases the taurine level as well as the total amino acid level, 3. the ratio of taurine in the total amount of amino acids declined in the pigmented epthelium of the retina and in the peripheral part of the retina, while its rise was found in the cenral portion. Its ratio in the optic nerve did not change. It was also found that the parasympaticomimetic - pilocarpine which maintains the taurine level in the examined tissue structures at the required physiological levels, contributes to the maintenance of their morpholgical structures and physiological functions. At the same time it has a substantial therapeutic effect in the inhibition of signs of glaucoma in the structures of the eye.

        Key words: taurine concentrations in the posterior segment of the eye, function
       

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