Dendritic Antigen Presenting Cells in the Pathogenesis of Psoriasis
Štork J.1, Klubal R.2, Vosmík F.1
1Dermatologická klinika 1. LF UK, VFN, Praha 2 přednosta doc. MUDr. J. Štork, CSc. 2Oddělení imunologie, 2. LF UK, FN Motol přednostka doc. MUDr. J. Bartůňková, DrSc. |
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Summary:
Background: In the last years, psoriasis is by a greater number of authors considered as T-cell
mediated disease of autoimmune nature. Dendritic cells, namely these expressing FXIIIa, represent
one of the three most proliferative cell population in psoriatic lesional skin. Because these cells are
capable to present antigen to T-cells, it is probable, that they can play a role in the pathogenesis of
psoriasis. In the literature described alterations of epidermal basement membrane structures can
be the basis of penetration of such cell subtypes in the epidermis, which, under normal conditions,
there are not present.
Objective: To verify if the presence of dendritic CA1a-/FcRI-DR+CD68+FXIIIa+ cells in the psoriatic
lesional epidermis and dermis, in comparison with perilesional psoriatic skin and other dermatosis
and healthy control, is characteristic feature of psoriasis. To verify if the potential alterations
of epidermal basal membrane integrity are in relation to the presence of this subtype of dendritic
cells.
Methods: Simple and double-labelling imunofluorescence technique with the use of labelled
antibodies were used in identification of these cell subtypes in patients with psoriasis, morphea,
systemic scleroderma, atopic eczema and healthy controls. Results: Dendritic CD1a-/FcRI-DR+CD68+FXIIIa+ cells were present only in the psoriatic epidermis.
Alterations of epidermal basement membrane were not found.
Conclusions: The presence of dendritic CD1a-/FcRI-DR+CD68+FXIIIa+ cells in the psoriatic
epidermis and their absence in the epidermis of other investigated dermatoses support the hypothesis
of their, otherwise not specified, pathogenetic role in the pathogenesis of this disease. Alterations
of the epidermal basement membrane integrity were not confirmed, probably because of not
sufficiently sensitive technique used for its detection.
Key words:
psoriasis - epidermis - dendritic CD1a-/FcRI-DR+CD68+FXIIIa+ cells
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