|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Vnitř. Lék., 50, 2004, No. 6, p. 453 - 461|
Infection and Hemostasis
Hudeček J., Paceková M., Chudej J., Kubisz P.
Klinika hematológie a transfuziológie JLF UK a MFN, Martin, Slovenská republika, přednosta prof. MUDr. P. Kubisz, DrSc.
Localised and following systemic inflammatory reaction accompanying progression of infection
causes generation of anti-inflammatory cytokines. They activate leucocytes, endothelium, coagulation
and fibrinolysis. Sepsis is usually accompanied by already decompensated disseminated
intravascular coagulation which significantly affects mortality of patients with this disease. The
main cause of hypercoagulation state during sepsis seems to be inhibition of fibrinolysis as
a result of overproduction of plasminogen activator inhibitor-1 in later stages of the disease.
Some microorganisms have specific properties which affect individual components of hemostasis
and thus increase their virulence. Because natural inhibitors of coagulation have not only anticoagulation
but also strong anti-inflammatory effect, they seem to be an optimum remedy for fluorid
coagulopathy during sepsis. Moreover, their use usually does not increase risk of bleeding.
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