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  Česky / Czech version Pracov. Lék., 53, 2001, No. 1, p. 59-61
 
Changes of Elastase 1 in Faeces of Diabetic Subjects 
Dítě P., Tomečková T., Dolina J., Novotný I., Prášek J., Žáková A., Dastych M.: 

Interní/gastroenterologická klinika FN MU, Brno
 


Summary:

       Diabetes mellitus is associated in some patients with exocrine pancreatic insufficiency. This applies in parti- cular to type 1 diabetics. Examination of the external pancreatic secretion is assessed by pretentious and expensive tests using stimulation of the gland by enterohormones, because non-invasive tests are not suffici- ently sensitive for evaluation of the external pancreatic secretion if a mild morphological form of pancreatopathy is involved. Based on their own experience with examination of changes of elastase 1 in faeces, where the authors proved in 70.0 % a reduction already in medium severe forms of chronic pancreatitis (classificati- on according to ERCP), a group of subjects suffering from type 1 diabetes and type 2 diabetes was examined. The exocrine pancreatic secretion was reduced in 60.0 % of subjects with type 1 diabetes and only in 5.0 % with type 2 diabetes. This result correlated with the C-peptide level and was not affected by the blood sugar level at the time. The authors draw attention to the fact that in subjects with type 1 diabetes where even during compensation loss of body weight persists, it is important to consider possible exocrine pancreatic insufficiency and supplement the patients with pancreatic enzymes.

        Key words: diabetes mellitus – elastase 1 – exocrine pancreatic function
       

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