Dermatoscopy is a modern non-invasive method of investigation broadening the potential of common clinical visual examination. In dermatology, it is applied foremost in the differential diagnosis of pigmented skin lesions in vivo. Digitalized dermatoscopy uses computerized high-resolution optical equipment rendering true-colour dermatoscopical findings. Advantages of the method are the ability to adjust the magnification in the course of examining, as well as digitalization, clearly arranged archiving and simple comparison of dermatoscopical findings. The apparatuses usually enable an automatic digitalized analysis of selected lesions. The authors present their initial experience with the application of digitalized dermatoscopy as an above-standard method in the investigation of difficult from the diagnostic point of view melanocytic as well as non-melanocytic lesions in the skin, and the follow-up of at-risk patients at the University Hospital Department of Dermatology in Pilsen.

        Key words: digitalized dermatoscopy - pigmented skin lesions - differential diagnostics - follow-up