Eighteen patients suffering of retinoblastoma during three years period (1999- 2001) were treated in two departments of ophthalmology in the Czech Republic. In four cases, the involvement was bilateral. In six eyes, because of very late stage of the disease at the time of diagnosis, the initial treatment was the enucleation. The rest, (sixteen eyes) was treated by chemoreduction (chemotherapy) and different combinations of local therapeutic methods according to their respective findings. Nine eyes from this cohort were enucleated in different period of time after the beginning of the treatment because of the relapse of the disease, its continuing or complications of the treatment. In the remaining seven eyes there are no sings of tumor activity. The fractioned radiotherapy was used in the treatment in one eye only and this eye was enucleated subsequently. So the maintaining therapy was successful in seven eyes of sixteen involved, or in 43.75% of cases.

        Key words: retinoblastoma,chemoreduction(chemotherapy), transpupillary thermotherapy, radiotherapy, tumors of the eye