CzMA JEP Home page CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ
Journals - Article
CzMA JEP Home page News About Assocation Publishing Division Medical Journals Searching Supplements Catalogue
 
  Česky / Czech version Pracov. Lék., 53, 2001, No. 1, p. 39-42
 
Permeability of the Gut in the Diagnosis of Coeliac Disease in Adults and Monitoring of Adherence to a Gluten-free Diet by these Patients 
Kohout P. 

Klinika gerontologická a metabolická, Fakultní nemocnice v Hradci Králové
 


Summary:

       The author examined the gut permeability using the test with lactulose, mannitol and D-xylose in patients with coeliac disease. The investigation comprised 30 patients with coeliac disease before they started a glutenfree diet. As control group served 30 patients without organic affliction of the digestive tract. Intestinal permeability is significantly greater when using the indexes lactulose/mannitol and lactulose/D-xylose in patients with untreated coeliac disease. In 23 patients the authors followed-up the value of intestinal permeability before the gluten-free diet and 2–6 months after adherence to the diet (checked by reduction or normalization of antibodies against gliadin, and/or endomysin and reticulin). The value of gut permeability assessed by indexes lactulose/mannitol and lactulose/D-xylose declined significantly, however, they did not reach normal values. The test of intestinal permeability is a suitable supplement, a noninvasive test in the diagnosis of coeliac disease and monitoring of compliance of gluten-free diet.

        Key words: coeliac disease – gluten-free diet – intestinal permeability – lactulose – mannitol – D-xylose
       

Order this issue

  BACK TO CONTENTS  
 
 
| HOME PAGE | CODE PAGE | CZECH VERSION |
©  1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o.
WEBMASTER